| 000 -LEADER |
|---|
| fixed length control field |
03417cam a22003495a 4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
16111686 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140428100211.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
100226s2009 sz ad b 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9789241572392 |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
UG |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Principles for modelling dose-response for the risk assessment of chemicals / |
| Statement of responsibility, etc |
first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc |
Geneva, Switzerland : |
| Name of publisher, distributor, etc |
World Health Organization, |
| Date of publication, distribution, etc |
c2009. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xx, 137 p. : |
| Other physical details |
ill., charts ; |
| Dimensions |
21 cm. |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
(Environmental health criteria : |
| Volume number/sequential designation |
239) |
| 500 ## - GENERAL NOTE |
|---|
| General note |
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Bibliography (p. 103-110). |
| 505 2# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations. |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc |
This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Drugs |
| General subdivision |
Dose-response relationship. |
| 9 (RLIN) |
47932 |
|
|---|
| Topical term or geographic name as entry element |
Risk assessment. |
| 9 (RLIN) |
47933 |
|
|---|
| Topical term or geographic name as entry element |
Dose-Response Relationship, Drug. |
| 9 (RLIN) |
47934 |
|
|---|
| Topical term or geographic name as entry element |
Dose-Response Relationship, Radiation. |
| 9 (RLIN) |
47935 |
|
|---|
| Topical term or geographic name as entry element |
Risk Assessment. |
| 9 (RLIN) |
47936 |
|
|---|
| Topical term or geographic name as entry element |
Environmental exposure. |
| 9 (RLIN) |
47937 |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
World Health Organization. |
| 9 (RLIN) |
47938 |
|
|---|
| Corporate name or jurisdiction name as entry element |
United Nations Environment Programme. |
| 9 (RLIN) |
47939 |
|
|---|
| Corporate name or jurisdiction name as entry element |
International Labour Organisation. |
| 9 (RLIN) |
47940 |
|
|---|
| Corporate name or jurisdiction name as entry element |
Inter-Organization Programme for the Sound Management of Chemicals. |
| 9 (RLIN) |
47941 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://whqlibdoc.who.int/publications/2009/9789241572392_eng.pdf |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Verified |
JW |